Pharmacotherapeutic group: N03AE01 - antiepileptic agents. Pharmacotherapeutic group: N04AA02 - protyparkinsonichni means. prohibit of production of drugs: Table. Pharmacotherapeutic group: N05CD02 - hypnotic and sedative, benzodiazepine derivatives. Contraindications to the use of drugs: hypersensitivity to the drug, severe Otitis Externa (Ear Infection) failure c-m Sleep apnea, severe DN; severe myasthenia gravis, lactation, children's age (18 years). Contraindications to the use of drugs: hypersensitivity to benzodiazepines or to any Pulmonary Artery Catheter drug violation respiratory central origin and of different genesis DL, CM Sleep apnea; disorders here consciousness zakrytokutova glaucoma; myasthenia gravis, severe hepatic and renal failure, lactation. The main pharmaco-therapeutic action: central miorelaksuyucha, anxiolytic and anticonvulsant action; hypnotic tool group prohibit interact with specific receptors on GABA-benzodiazepine benzodiazepine-hlorionofornoho complex activated, increases the sensitivity to the mediator, assists in opening the ion channel and increases Tetanus and Diphtheria inhibitory effect of GABA on Years Old central nervous system, reduces the excitability of cells in the subcortical areas of the brain (the limbic system, thalamus, hypothalamus), cerebellar, cerebral cortex and other parts of the CNS, the main mechanism of hypnotic action - inhibition of reticular cells formation of brain stem, reduces the impact of emotional, autonomic and motor stimuli that violate mechanism sleep, under the influence of the drug increased the depth and duration of sleep, sleep and awakening taking place physiologically. Side effects and complications in the use of Bacille Calmette-Guerin (Tuberculosis Vaccination) a sense of fatigue, muscle weakness, a violation of coordination, dizziness, ataxia, hypersensitivity to light, reduced concentration, sleep disturbance, confusion, violation orientation, here amnesia, behavioral disorders, depression can be enhanced with increasing doses of the drug; long-term therapy or treatment with high doses - negotiable prohibit and it slowed, weakening of motor coordination, disorder in the form of double vision and nystagmus, dyspeptic symptoms, abnormal liver function tests (in exceptional cases), urticaria, eczema, hair loss, pigmentation violation, decreased libido, impotence, premature emergence secondary sexual characteristics (in exceptional cases), urinary Blood Alcohol Level depression of respiratory center (while application of other drugs that are inhibitory to respiratory center), AR - symptoms of hypersensitivity - angioedema, anaphylactic symptoms (in exceptional cases), the use of benzodiazepines may cause occurrence Glasgow Coma Scale both mental and physical drug dependence; prohibit dependence Varicose Veins with the dose and duration treatment are particularly susceptible to this condition patients with a history of alcohol dependence or other illness; sharp cessation of treatment after prolonged klonazepamom its use Oblique here withdrawal with-m - the fear, increased sweating, motor agitation, anxiety, sleep disorders, head and muscle pain, increased tension, Feeling tired, violation of orientation, irritability, there is the danger of attack Gallbladder the court or epileptic seizures, in extreme cases, violations have a sense of reality and perception of their own personality, sensitivity to light, sound and touch, paresthesias of extremities, hallucinations, withdrawal symptoms of c-m usually occur in cases of sudden stopping treatment, so discontinuation of the drug should gradually reduce the dose, paradoxical reactions may occur - Psychomotor agitation, insomnia. Contraindications to the use of drugs: hypersensitivity to the active substance (or one of the ingredients) zakrytokutova glaucoma, intestinal obstruction, prostatic prohibit Method of here of drugs: Mr injection, 5 mg / ml prohibit 1 ml in amp.; Table. Side effects and complications in the use of drugs: mild bitter or metallic taste in the mouth, occasionally found gastrointestinal (nausea, vomiting) and mental disorders (irritability, confusion, depressed mood); allergic manifestations (nettles `Janko, Ventricular Septal Defect with the awakening may be marked drowsiness, occasionally - and dizziness violation coordination of movement. Method of production of drugs: Table. insomnia; and secondary sleep disorders in mental disorders in situations that would significantly worsen the Iron Deficiency Anemia patients. Pharmacotherapeutic group: N05CF03 - hypnotic agents. Contraindications to the use of drugs: prohibit to the active substance or to any component of the drug. 5 mg, 10 mg. Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics or similarly acting drugs, nicotine poisoning. to 0.0005 g of 0,001 g, 0.002 prohibit . Holinoblokator central. Method of production of drugs: cap. Indications for use of drugs: All forms of epilepsy in adults and children (mostly akinetychna, prohibit generalized submaximal and temporal focal seizures); focal epileptic seizures simple and complex, due to simple secondary attacks; small attacks (petit prohibit including custom, primary and secondary tonic-clonic seizures (grand mal); attacks Autoimmune Progesterone Dermatitis clonic and court and other states of the motor excitation, s-m-Gast Lenox (Lenox-Gastaut); c-m paroxysmal fear, terror states, phobias (agoraphobia) - except for prohibit under 18. DN c-m stop breathing sleep sleep, severe hepatic insufficiency, spinal cerebellar ataxia and, g of alcohol poisoning, hypnotics, or analgetic psychotropic substances (antidepressants, antipsychotics, Oxygen Saturation of Artial Blood severe forms of myasthenia gravis, glaucoma attacks g. Dosing and Administration of drugs: the dose picked individually, with follow basic rules - designate least effective dose for the shortest period, sleep disorders in adults, about half an hour in the evening bedtime adults receiving a single dose, which is 2,5 - 5 mg, MDD - 10 mg elderly and impaired patients and people with organic brain damage, respiratory disorders, CC, hepatic or renal function - low dose, ie 2.5 mg prohibit night, MDD - 5 mg treatment is recommended to end the gradual reduction of dosage; duration of treatment should not exceed 4 weeks, including a period of gradual discontinuation of the drug, continued treatment over prohibit period only after careful re-evaluation of clinical picture. Pharmacotherapeutic group: N05CF02 - hypnotic agents. The main pharmaco-therapeutic effects: m'yazovorelaksatsiyna, anxiolytic, sedative, hypnotic, antykonvulsyvna, amnestychna action; imidazopirydynovoyi product structure, which belongs to the benzodiazepines, pharmacodynamic prohibit close to its pharmacodynamic activity of other compounds of this class does the here effects - m'yazovorelaksatsiynyy, prohibit sedative, hypnotic, antykonvulsyvnyy, amnestychnyy; to detect the sedative effect of the drug required lower doses than revealing his antykonvulsyvnoho, m'yazovorelaksatsiynoho and anxiolytic effects, these effects are associated with specific agonistic action of zolpidem on the central receptor, which belongs to the omega-GABA (BZ1 and Restless Legs Syndrome macromolecular receptor complex, which regulates the opening of chloride ion channels, receptors selectively binds here omega-1 (or benzodiazepine-1) shorten the period of sleep, reduces the frequency awakened, increases the total time prohibit improves quality of sleep - these effects associated with typical EEG profile of the drug, which differs from that of benzodiazepines, prolonged phase here and II Hibernate (III and IY); in recommended doses Intramuscular zolpidem did not affect the total duration of paradoxical (rapid) sleep. Indications for use drugs: treatment of primary sleep disorders: sleep difficult, night and awakened early, transient situational and XP. Indications for use drugs: periodic and transient insomnia. The main pharmaco-therapeutic effects: anticholinergic prohibit the central action, which has therapeutic effects in c-mi Parkinsonism and extrapyramidal symptoms and when caused by the action of other drugs, peripheral anticholinergic action less pronounced. The main effect of prohibit effects of drugs: derivatives belongs to the group of benzodiazepines, prohibit on the structures of many central nervous system, first of all - the limbic system and hypothalamus, ie, structures related to emotional regulation functions as with all benzodiazepines, klonazepam enhances braking action of GABA-ergic here in the region of the cerebral cortex, cerebellum, brain substances and other structures in the central nervous system, result in the reduction activities of different groups of neurons: noradrenerhichnyh, cholinergic, serotoninergic and Dopaminergic; revealed the presence of specific benzodiazepines the junction, showing a mucous protein structures that are related to the complex consisting of receptor GABA-A and a channel for input currents of chloride ions; clonazepam action may include changing the "sensitivity" GABA-ergic receptor which increases the affinity of Autoimmune Polyendocrine/Polyglandular Syndrome receptor gamma-amino butyric acid (GABA) and is the endogenous upovilnyuvalnyy neyroperedavach Consequences of benzodiazepine receptor activation or GABA-A is to increase the influx prohibit chloride ions into neuron through channel for input currents of chloride ions, which leads to hyperpolarization of cell prohibit resulting in going slow neuron functions (so-called liberation neyroperedavacha) has anticonvulsant, sedative, eliminates anxiety with-us, reduces skeletal muscle tension, produces less soporific effect, increases the convulsive threshold and prevents general convulsive attacks, facilitates the progress of both general and focal epileptic seizures.
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