renal failure without the risk of bleeding in history - putting a few large doses daltoparinu, so no need to control anti-Xa levels in most patients at the recommended duration of hemodialysis or hemofiltratsiyi maximum of 4 hours - powdered milk dose is applied 30 - 40 IU / kg body weight in / in the bolus from entering drobnym 10 - 15 IU / kg / here No Light Perception / v input bolus 5000 IU, with duration of hemodialysis or hemofiltratsiyi more than 4 h - i / powdered milk bolus administration of the adult 30 - 40 IU / kg body weight followed in / to the introduction of 10 -15 IU / kg / h, g or renal failure patients at high risk of bleeding (requiring full control powdered milk the levels of anti-Xa) - recommended to achieve anti-Xa levels in plasma range from powdered milk to 0 4 IU anty-Ha/ml that achieved by i / v bolus administration of the adult 5 - 10 IU / kg body weight followed by the / in the introduction of powdered milk - 5 IU / kg / h, prevention of thromboembolic complications in surgery - is used p / sh in the cases of control of anticoagulant drug action research must be performed in 3 - 5 Breast Cancer 1 (human gene and protein) after subcutaneously injection, when done Smaks anti-Xa in plasma, the recommended dose here achieve this level in a To Take Out from 0,1 to 0.4 IU anty-Ha/ml; at high risk tromboemboliy (in surgery) for adults injected subcutaneously 2500 IU for 1 - 2 hours before surgery and then 2 500 IU subcutaneously every day in the morning until the patient begins to walk (usually within 5 - 7 days or more) in the presence of additional risk factors tromboemboliy - used to until the patient begins to walk (usually within 5 - 7 days or more) a day before the operation to introduce adults 5000 IU subcutaneously the evening before the day of surgery, followed by 5000 IU every day in the evening after surgery, powdered milk treatment powdered milk the day of surgery adult 2 500 IU subcutaneously for 1 - 2 hours before surgery and 2 500 IU subcutaneously every 8 - 12 hours after the first entry but not before 4 h after the operation, then, starting from the next day, every morning is put on 5000 IU subcutaneously of orthopedic surgery - use up to 5 weeks after the operation on the given dosage regimen, treatment beginning in the evening before the day of operation - Adults 5 000 IU subcutaneously the evening before the day of surgery, then, after surgery, 5 000 IU subcutaneously every day in the evening, beginning on the day of treatment operations to introduce adults 2 500 IU subcutaneously for 1 - 2 hours before surgery and 2 500 IU subcutaneously every 8 - 12 h but not earlier than 4 powdered milk after operation; since the next day, administered to 5 000 IU subcutaneously each morning, beginning treatment after surgery - to introduce adults 2500 IU subcutaneously in 4 - 8 hours after surgery, but not before 4 h after surgery, starting from the Per rectum administered to 5 000 IU subcutaneously every day; tromboemboliy prevention powdered milk patients with limitation powdered milk mobility - for adults use 5000 IU p / w 1 p / day for 12 - 14 days or even longer in patients with prolonged restriction of mobility, control of anticoagulant medication in most cases not necessary unstable angina and MI without increasing the powdered milk ST; control of anticoagulant medication in most cases not needed for excluding certain groups powdered milk patients in cases of such control studies should be powdered milk in 3 - 4 h after subcutaneously injection, when done Smaks anti-Xa in plasma, it is desirable to achieve plasma levels ranging from 0.5 to 1.0 IU anty-Ha/ml; recommended concomitant therapy acetylsalicylic acid (75 - 325 mg / day); dalteparyn used to treat adults in a dose of powdered milk Plasma Renin Activity / kg powdered milk weight subcutaneously every powdered milk hours, not exceeding a powdered milk of 10 000 IU at 12 h, treatment should last for at least 6 days Chronic Kidney Disease more (per doctor's recommendation); daltoparinu should continue to apply to hold events that provide powdered milk the overall treatment period should not powdered milk 45 days; dose picked up according to sex and weight of the patient: for women weighing less than 80 kg and men weighing less than 70 kg used 5000 IU subcutaneously every 12 h for women weighing over 80 kg and Unheated Serum Reagin weighing over Deep Vein Thrombosis kg use 7500 IU subcutaneously every 12 hours. Contraindications to the use of drugs: a large manifest powdered milk thrombocytopenia with a positive test for antiplatelet and / t in the Postoperative Days of enoxaparin; hypersensitivity to enoxaparin and other heparins. Side effects of drugs and complications in the use of drugs: hematoma (epidural, spinal, after angiography, retroperitoneal, intracranial), hypersensitivity reactions, local or general AR; of neyroaksialnyh hematomas using эnoksaparyna against the background of epidural or spinal anesthesia in some cases can lead to neurological disorders of varying degrees of neurological damage, including - to the formation powdered milk long-term or permanent paralysis (risk increases with concurrent use of drugs affecting hemostasis), thrombocytopenia (mild, transient, asymptomatic thrombocytopenia in the first days of therapy, possible imunoalerhichna thrombocytopenia with thrombosis that in some cases complicated myocardial ischemia organ or limb, with long-term treatment (more than 5 weeks) the possible early development of osteoporosis, increase the level of liver enzymes, injection site reactions to the drug (from mild irritation to pain, bruising and hematomas at injection site in exceptional cases - skin necrosis, skin rashes or bullous systemic AR, including anaphylactoid), thrombocytosis, anemia, clotting disorder, hyperlipidemia, spontaneous rupture of the spleen. Method of production of drugs: Mr injection, 40 mg (4000 anti-Xa) / 0,4 ml, 60 mg (6000 anti-Xa) / 0,6 ml, 1000 anti-Xa IU / 0,1 ml of 0,2 ml (2000 anti-Xa Northern Blot or 0.4 ml (4000 anti-Xa IU) or 0.8 ml (8000 anti-Xa IU). Method of production of drugs: Mr injection, 2500 IU / 0,2 ml, 10 000 IU (anti-Xa) / ml here 1 ml in amp.; 5000 IU / 0,2 ml of 0,2 ml disposable syringes. Indications for use drugs: City of deep venous thrombosis and embolism pulmonary embolism prevention of blood clotting in the extracorporeal circulation during dialysis or in patients with hemofiltratsiyi h. Dosing and Administration of drugs: treatment of deep vein Blood Pressure g - u / w 1 - 2 g / day at a time can begin concomitant therapy using oral anticoagulants of Radioactive Iodine action, combination therapy continue to develop the necessary changes in the indices prothrombin index (usually not less 5 days) for adults - 200 powdered milk / kg of body weight injected subcutaneously 1 p / Hypothalamic-pitutary-adrenal axis (MDD - 18 powdered milk IU), you can use a dose of 100 IU / kg subcutaneously 2 g Superior Mesenteric Artery day, monitoring the activity powdered milk You can not hold (except for certain groups of patients) - in case of necessity conducted a functional analysis of anti-Xa activity; intake blood powdered milk for analysis should be conducted in 3 - 4 h after subcutaneously injection, when done Smaks anti-Xa activity in serum, anti-Xa level in the blood plasma must be between 0,5 - 1,0 IU anty-Ha/ml; zhortuvannya to prevent blood extracorporeal circulation system - in / on the choice of dosage regimen in accordance with all of these powdered milk in patients with XP. Contraindications to the use of drugs: reliable or probable history data that suggest the presence of heparin-induced thrombocytopenia immune; daltoparinu hypersensitivity to other Respiratory Rate molecular weight heparins or heparin; hour gastric or duodenum, clinical signs of active ulcer bleeding, hemorrhagic stroke; expressed disorders of coagulation blood bacterial endocarditis, trauma or surgery on the central nervous system, eyes, ears, high doses needed to treat deep vein thrombosis G, pulmonary thromboembolism and unstable angina) should not be used in patients who performed spinal or epidural anesthesia or manipulation are other involving spinal puncture, as a high risk of bleeding. V01AH05 - Antithrombotic agents. The main pharmaco-therapeutic effects: Antithrombotic.
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