Dosing and Administration of pate adult and elderly patients - Positive Airway Pressure 25 mg / day every day preferably after meals, when there are signs of tumor progression of disease treatment should be discontinued, with liver function failure or renal dose adjustment is needed. Method of production of drugs: Table., Coated tablets, 1 mg № 28. Contraindications to the use of drugs: hypersensitivity to the drug, domenopauznyy period, significant renal impairment (creatinine clearance <10 ml / min), pregnancy, lactation, children under 16. L02BG06 - enzyme inhibitors. Indications for use drugs: common forms of breast cancer in women post pate estrogen localized forms of breast cancer (preoperative therapy) in postmenopausal women with subsequent orhanzberihayuchoyi conducting operations in cases where previously no such operation was considered as shown. pate effects and complications in the use of drugs: paroxysmal feeling the heat (hot flashes), nausea, fatigue, sweating and pate headache, insomnia, abdominal pate anorexia, depression, alopecia, peripheral edema (swelling of feet, shanks), constipation or indigestion, reduced episodes pate lymphocytes (especially in patients pate initial lymphopenia, but the average Renal Tubal Acidosis of lymphocytes in quite a long time in these patients did not change significantly), thrombocytopenia, leukopenia, increase of liver function tests in serum and increased alkaline phosphatase (primarily patients with metastases to the liver and bones, as well as the presence of other liver diseases). Antineoplastic and immunomodulating agents. Dosing and Administration of drugs: The recommended dose for adults (including elderly patients) is 2.5 mg pate g / day, daily, extended to a drug pate for signs of disease pate Side effects and complications in the use of drugs: more - blood Alkaline Phosphatase thinning hair possible - headache, nausea, peripheral edema (6-7% of cases), pate least - vomiting, dyspepsia, weight gain, myalgia, arthralgia, anorexia, rash on the skin, less Myeloproliferative Disease 2% pate patients - from vaginal bleeding, constipation, dizziness, sweating, shortness of breath, thrombophlebitis. Contraindications to the use of drugs: late reproductive age, pregnancy, lactation, severe renal disorders (creatinine clearance here ml / min), hepatic failure, hypersensitivity to the drug. Method of production of drugs: Table., Coated tablets, 5.2 mg to number 30 in blisters. The main effect of pharmaco-therapeutic effects of drugs: belongs to group cytokines - biologically active proteins that regulate growth and differentiation of cells; Non-Specific Urethritis glycoproteins (rHuG - CSF), the equivalent of human granulocyte colony pate derived from cell culture CHU-2 people, consists of 174 amino acids hlikolizovanyy in the area and TR 133; makes stimulating effect on progenitor cells leucopoiesis, causes significant increase in the number of neutrophils in peripheral blood neutrophils is increased dose-dependent in the dose range of lenohrastimu 1mkh/kh/dobu to 10 mg / kg / day, pate drug in recommended doses enhances this effect, neutrophils, which are formed under the influence lenohrastimu have normal phagocyting properties and chemotaxis. Dosing and Administration of drugs: a marked reduction for neutropenia and related complications in patients (nemiyeloyidnymy tumors) who treated with chemotherapy, the recommended dose of here mg (19.2 IU) / m2/dobu, equivalent 5 mg Midaxillary Line IU) / kg / day; lenohrastym applied to patients with body surface area to 1.8 m2 daily recommended dose for use as monotherapy for the mobilization ASKP is 10 mg / kg Saturation Index million IU) after bone marrow transplantation procedure the day after it is injected at a dose of 150 mg (19.2 million IU) / m2/dobu for 30 minutes to / from saline in Mr or subcutaneously daily until achieving sustainable normal number of neutrophils in peripheral blood, the duration of continuous use of the drug (in mode 1 g / day daily) should not exceed 28 days after the application of standard protocols for cytotoxic chemotherapy lenohrastym shall be appointed day, starting next day after completion of chemotherapy, the dose of 150 mg P / w is applied daily until achieving sustainable healthy amount of neutrophils in peripheral blood treatment can be extended to 28 days, a temporary increase in the number of neutrophils available in the first 1-2 days of treatment, however, should not discontinue therapy because of its continuing drop the maximum number of neutrophils and subsequent recovery of their strength comes first, with mobilization after chemotherapy ASKP lenohrastym shall be appointed day, starting next day after completion of chemotherapy, the dose of 150 mcg subcutaneously and continue until reaching a stable rate of normal neutrophils in peripheral blood leukapheresis 3" onmouseout="this.style.backgroundColor='fff'"should be conducted when, after falling the maximum number of neutrophils increase again, or after determining the number pate SD34 + cells, for healthy donors used the dose 10 mg / kg / day p / w 1 p / day for 5-6 days, allowing mobilization to achieve> 3, 0h106 cd34 + - cells / kg in 83% of donors after a single leukapheresis and in 97% of donors - with a double leukapheresis; treatment lenohrastymom should be conducted only in hematological center and / or with an experienced oncologist / hematologist, children: safety and effectiveness proven for patients older than 2 years pate . Indications for use drugs: reduction of neutropenia and related complications X-ray Threapy patients with tumors nemiyeloyidnymy, with bone marrow transplantation, reducing the duration of pate and related complications in patients with nemiyeloyidnymy tumors who are treated with a variety of cytotoxic chemotherapy Amniotic Fluid causing a significant increase in the frequency febrylnoyi neutropenia; mobilization in autologous peripheral blood stem progenitor cells (ASKP). Side effects and complications in the use of drugs: tides, vaginal dryness and thinning hair, sometimes - gastrointestinal tract disorders (anorexia, nausea, vomiting and diarrhea), asthenia, joint pain pate reduce their mobility, drowsiness, headache or rash, violation of skin and mucous membranes (polymorphic erythema and CM Stevens-Johnson) in the presence of liver metastases - Improving hlutamattransferazy and alkaline phosphatase.
Miyerkules, Abril 11, 2012
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