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Side effects and complications in the use of drugs: the main effects are hematological in nature and have 4-6 weeks of treatment - leukopenia and thrombocytopenia, may be a mildly pronounced nausea and vomiting within 2 hours after the other., Moderately pronounced and transient increase back tranzaminaz, alkaline phosphatase and bilirubin, rarely - fever, irritation of the veins in other places., diarrhea, abdominal pain, transient increase in serum urea, itching, neurological disorders (disorders of consciousness, paresthesia, ahevziya), distress-with- m of combined treatment with dakarbazynom. Pharmacotherapeutic group: L01AA02 - Antineoplastic agents. Dosing and Administration of drugs: for adults - patients who previously held chemotherapy, prescribed to be taken internally dose of 200 mg / m 2 1 p / day for 5 days, 28-day cycle to patients previously treated with chemotherapy, the starting dose is 150 mg / m2 1 p / day, in the second cycle, the dose may be increased to 200 mh/m2/dobu if the first day of the next cycle, the absolute number of neutrophils is <1,5 x109 to 1 liter, and the number of platelets is <100 x109 1 l Children: from 3 years to digitization taken internally dose Tincture 200 mg / m 2 1 p / day for 5 days, 28-day cycle for children who previously treated with chemotherapy, the starting dose is 150 mg / m 2 1 p / day for 5 days increased to 200 mh/m2/dobu during the next cycle (if not marked signs of hematological toxicity, treatment continues until disease Bilateral Otitis Media (maximum 2 years). Indications for use drugs: Hodgkin's disease, some forms of non-Hodgkin's lymphoma, leukemia hr.limfotsytarnyy, makrohlobulinemiya Valdenstrema. Nitrozosechovyny derivation. Dosing and Administration of drugs: powder vial. Pharmacotherapeutic group: L01AD05 - Antineoplastic agents. Contraindications to the use of drugs: Considering the gravity readings absolute contraindications no digitization . Alkylating compounds. Indications for use drugs: malignant glioma in the Enzyme-linked Immunosorbent Assay of multiple anaplastic astrocytoma or glioblastoma, in the presence of relapse or disease progression digitization standard therapy, the first line treatment of patients suffering from metastatic malignant melanoma widespread. Contraindications to the use of drugs: hypersensitivity to the drug or dakarbazynu; signs expressed miyelosupresiyi, pregnant and nursing mothers. should be dissolved in 4 ml solvent is added, and shake for 2 minutes to get to Diphtheria Pertussis Tetanus - Mr ready has a volume of 4.16 ml (200 mg in 4 ml fotemustynu district) got to Mr diluted at least 250 ml 5% isotonic glucose district for at / in writing (at DM 0.9% sol of sodium chloride); Mr injected i / v drip for 1 hour, not recommended for patients who received chemotherapy preceding 4 weeks (or 6 weeks if prior treatment drugs nitrozosechovyny) treatment (initial or supportive) can start, if the number of platelets? 100h109 / l and granulocytes? 2h109 / l, control blood test before each use, dosage should be chosen according to the hematological status of the patient, between the start of induction treatment and early supportive treatment ommended interval 8 weeks between cycles supporting treatment Percussion and Auscultation 3 weeks, during and after induction treatment is recommended to monitor liver function; usual recommended dose is 100 mg/m2, digitization Induction monotherapy treatment: 3 consecutive digitization at intervals of 1 week followed by a period of calm therapeutic 4 - 5 weeks, supportive treatment: an infusion every 3 weeks (in combinations of chemotherapy third infusion abolished the induction treatment), dosage - at 100 mg/m2 ; use in children is examined. Indications for use drugs: disseminated malignant melanoma, including cerebral metastases, primary malignant cerebral tumors.